1R3N

Crystal structure of beta-alanine synthase from Saccharomyces kluyveri

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1r3na1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
A	d1r3na2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
B	d1r3nb1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
B	d1r3nb2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
C	d1r3nc1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
C	d1r3nc2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
G	d1r3ng1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
G	d1r3ng2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
D	d1r3nd1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
D	d1r3nd2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
E	d1r3ne1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
E	d1r3ne2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
F	d1r3nf1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
F	d1r3nf2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
H	d1r3nh1	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Bacterial dinuclear zinc exopeptidases	Peptidase-like beta-alanine synthase, catalytic domain	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)
H	d1r3nh2	Alpha and beta proteins (a+b)	Ferredoxin-like	Bacterial exopeptidase dimerisation domain	Bacterial exopeptidase dimerisation domain	Peptidase-like beta-alanine synthase	(Lachancea kluyveri ) [TaxId: 4934 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Bacterial dinuclear zinc exopeptidases	8027942	4000587	SCOP2 (2022-06-29)
A	SCOP2 Family	Bacterial exopeptidase dimerisation domain	8027943	4001271	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Bacterial exopeptidase dimerisation domain	8040322	3001194	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Zn-dependent exopeptidases	8040321	3000662	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	M20_dimer	e1r3nA1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
A	Peptidase_M28	e1r3nA2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
B	M20_dimer	e1r3nB1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
B	Peptidase_M28	e1r3nB2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
C	M20_dimer	e1r3nC1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
C	Peptidase_M28	e1r3nC2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
G	M20_dimer	e1r3nG1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
G	Peptidase_M28	e1r3nG2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
D	M20_dimer	e1r3nD1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
D	Peptidase_M28	e1r3nD2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
E	M20_dimer	e1r3nE1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
E	Peptidase_M28	e1r3nE2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
F	M20_dimer	e1r3nF1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
F	Peptidase_M28	e1r3nF2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
H	M20_dimer	e1r3nH1	A: a+b two layers	X: Alpha-beta plaits	H: Bacterial exopeptidase dimerisation domain (From Topology)	T: Bacterial exopeptidase dimerisation domain	F: M20_dimer	ECOD (1.6)
H	Peptidase_M28	e1r3nH2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
A	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
B	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
B	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
C	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
C	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
G	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
G	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
D	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
D	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
E	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
E	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
F	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
F	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
H	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
H	3.30.70.360	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01546	Peptidase family M20/M25/M40 (Peptidase_M20)	Peptidase family M20/M25/M40	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF07687	Peptidase dimerisation domain (M20_dimer)	Peptidase dimerisation domain	This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases [1]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase ...	This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases [1]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [2]. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	beta-alanine synthase	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding ion binding binding metal ion binding small molecule binding beta-ureidopropionase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002933	Peptidase M20	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR010158	Amidase, carbamoylase-type	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036264	Bacterial exopeptidase dimerisation domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011650	Peptidase M20, dimerisation domain	Domain