1FM6

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth U]	d1fm6u_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Retinoid-X receptor alpha (RXR-alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1fm6a_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Retinoid-X receptor alpha (RXR-alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth D]	d1fm6d_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Peroxisome proliferator activated receptor gamma, PPAR-gamma	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth X]	d1fm6x_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Peroxisome proliferator activated receptor gamma, PPAR-gamma	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth U]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038695	3001442	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038695	3001442	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8035649	3001442	SCOP2B (2022-06-29)
D [auth X]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8035649	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth U]	Hormone_recep	e1fm6U1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
A	Hormone_recep	e1fm6A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
B [auth D]	Hormone_recep_1	e1fm6D1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)
D [auth X]	Hormone_recep_1	e1fm6X1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth U]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
B [auth D]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
D [auth X]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth U]	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain
B [auth D], D [auth X]	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth B], F [auth V], G [auth E], H [auth Y]	STEROID RECEPTOR COACTIVATOR	protein-containing complex binding binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding protein dimerization activity catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity protein-containing complex binding binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding protein dimerization activity catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding transcription factor binding nuclear retinoic acid receptor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding nuclear retinoid X receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development placenta development chordate embryonic development embryonic morphogenesis labyrinthine layer development embryo development in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis anatomical structure morphogenesis embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development ovulation cycle rhythmic process estrous cycle multicellular organismal reproductive process response to ketone response to lipid response to stimulus response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to progesterone response to oxygen-containing compound response to organic cyclic compound regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process cellular response to stimulus intracellular receptor signaling pathway signaling regulation of signal transduction regulation of thyroid hormone receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus regulation of intracellular signal transduction signal transduction cellular response to hormone stimulus regulation of signaling thyroid hormone receptor signaling pathway cellular response to chemical stimulus regulation of response to stimulus regulation of cell communication nuclear receptor-mediated signaling pathway head development brain development nervous system development cerebellum development central nervous system development metencephalon development hindbrain development behavior male mating behavior reproductive behavior mating behavior forebrain development pallium development cerebral cortex development telencephalon development nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to organic cyclic compound estrogen receptor signaling pathway cellular response to lipid peroxisome proliferator activated receptor signaling pathway mRNA transcription by RNA polymerase II RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process macromolecule metabolic process regulation of body fluid levels secretion transport mammary gland development gland development establishment of localization body fluid secretion localization lactation regulation of biological quality response to Thyroglobulin triiodothyronine cellular response to Thyroglobulin triiodothyronine progesterone receptor signaling pathway cellular response to nitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound regulation of cellular response to insulin stimulus cellular response to oxygen-containing compound response to insulin cellular response to insulin stimulus positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process hippocampus development limbic system development regulation of transcription from RNA polymerase II promoter by galactose carbon catabolite regulation of transcription positive regulation of transcription by galactose cellular response to nutrient levels carbon catabolite regulation of transcription from RNA polymerase II promoter carbon catabolite activation of transcription from RNA polymerase II promoter carbon catabolite activation of transcription response to nutrient levels regulation of transcription by galactose response to nutrient positive regulation of transcription from RNA polymerase II promoter by galactose cellular response to nutrient regulation of developmental process connective tissue development adipose tissue development positive regulation of adipose tissue development tissue development positive regulation of developmental process regulation of adipose tissue development positive regulation of multicellular organismal process regulation of multicellular organismal process hypothalamus development diencephalon development response to retinoic acid cellular developmental process regulation of cell differentiation positive regulation of neuron differentiation neurogenesis neuron differentiation positive regulation of cell differentiation cell differentiation generation of neurons regulation of neuron differentiation positive regulation of female receptivity female mating behavior regulation of female receptivity response to estradiol	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome RNA polymerase II transcription regulator complex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cell periphery plasma membrane membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
A, C [auth U]	RETINOIC ACID RECEPTOR RXR-ALPHA	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity LBD domain binding protein domain specific binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity retinoic acid binding organic acid binding isoprenoid binding retinoid binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding identical protein binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear vitamin D receptor binding retinoic acid-responsive element binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear steroid receptor activity DNA binding domain binding peptide binding cation binding transition metal ion binding zinc ion binding metal ion binding enzyme binding	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux regulation of transporter activity positive regulation of molecular function regulation of molecular function positive regulation of transporter activity multicellular organismal process regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus signaling response to endogenous stimulus retinoic acid receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular process signal transduction nuclear receptor-mediated signaling pathway cellular response to hormone stimulus peroxisome proliferator activated receptor signaling pathway mRNA transcription by RNA polymerase II RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process macromolecule metabolic process negative regulation of biological process regulation of primary metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular developmental process cell differentiation response to retinoic acid response to lipid response to oxygen-containing compound positive regulation of cell communication regulation of response to nutrient levels positive regulation of signal transduction regulation of signal transduction cellular response to vitamin D response to vitamin D response to organic cyclic compound cellular response to organic cyclic compound positive regulation of intracellular signal transduction cellular response to oxygen-containing compound cellular response to nutrient levels regulation of response to stimulus cellular response to lipid regulation of vitamin D receptor signaling pathway response to nutrient levels response to vitamin positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling response to nutrient vitamin D receptor signaling pathway cellular response to vitamin positive regulation of vitamin D receptor signaling pathway regulation of cell communication cellular response to nutrient positive regulation of signaling regulation of thyroid hormone receptor signaling pathway positive regulation of thyroid hormone receptor signaling pathway thyroid hormone receptor signaling pathway	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome receptor complex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome receptor complex membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle RNA polymerase II transcription regulator complex nucleus nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B [auth D], D [auth X]	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA	binding organic cyclic compound binding nucleic acid binding protein binding WW domain binding protein domain specific binding sequence-specific DNA binding DNA binding LBD domain binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity binding organic cyclic compound binding nucleic acid binding protein binding WW domain binding protein domain specific binding sequence-specific DNA binding DNA binding LBD domain binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity prostanoid receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity icosanoid receptor activity prostaglandin receptor activity cytoskeletal protein binding alpha-actinin binding actinin binding arachidonate binding fatty acid binding icosanoid binding organic acid binding long-chain fatty acid binding icosatetraenoic acid binding ion binding anion binding lipid binding carboxylic acid binding small molecule binding monocarboxylic acid binding DNA binding domain binding transcription factor binding nuclear retinoic acid receptor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding nuclear retinoid X receptor binding DNA-binding transcription factor binding E-box binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding SMAD binding R-SMAD binding STAT family protein binding transcription coregulator binding nuclear receptor activity ligand-activated transcription factor activity identical protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity chromatin binding peptide binding cation binding transition metal ion binding zinc ion binding metal ion binding enzyme binding	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication cellular process apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway organic anion transport carboxylic acid transport organic acid transport monocarboxylic acid transport fatty acid transport long-chain fatty acid transport intracellular receptor signaling pathway response to endogenous stimulus retinoic acid receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical nuclear receptor-mediated signaling pathway cellular response to hormone stimulus positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription response to type II interferon negative regulation of biological process response to cytokine regulation of type II interferon-mediated signaling pathway response to biotic stimulus cellular response to type II interferon negative regulation of response to type II interferon interferon-mediated signaling pathway cellular response to cytokine stimulus regulation of immune system process immune response response to other organism regulation of innate immune response negative regulation of immune response type II interferon-mediated signaling pathway response to external stimulus regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response regulation of response to type II interferon regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of signaling negative regulation of cell communication cytokine-mediated signaling pathway response to stress regulation of response to stress negative regulation of cellular process innate immune response response to external biotic stimulus negative regulation of type II interferon-mediated signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus defense response regulation of cytokine-mediated signaling pathway defense response to symbiont negative regulation of signal transduction response to peptide negative regulation of immune system process negative regulation of cytokine-mediated signaling pathway immune system process negative regulation of innate immune response developmental process cellular developmental process cell differentiation cell fate commitment peroxisome proliferator activated receptor signaling pathway mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process transcription by RNA polymerase II negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation regulation of vascular endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of vascular endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation vascular endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of molecular function regulation of molecular function positive regulation of low-density lipoprotein receptor activity regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process positive regulation of fatty acid metabolic process fatty acid metabolic process carboxylic acid metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process positive regulation of small molecule metabolic process lipid metabolic process rhythmic process circadian rhythm regulation of circadian rhythm chemical homeostasis homeostatic process lipid homeostasis negative regulation of extracellular matrix organization regulation of cellular component organization negative regulation of cellular component organization extracellular matrix organization regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly negative regulation of extracellular matrix assembly cellular component organization or biogenesis regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization negative regulation of inflammatory response regulation of inflammatory response inflammatory response anatomical structure maturation anatomical structure development cell development cell maturation developmental maturation negative regulation of miRNA transcription negative regulation of miRNA metabolic process negative regulation of intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade MAPK cascade negative regulation of MAPK cascade cell surface receptor signaling pathway via STAT negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cellular response to nitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound response to insulin cellular response to insulin stimulus multicellular organismal process regulation of developmental process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis system development blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process muscle cell apoptotic process positive regulation of smooth muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process positive regulation of muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process negative regulation of gene expression cellular response to growth factor stimulus regulation of cellular response to transforming growth factor beta stimulus cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus negative regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta response to growth factor mitochondrion organization organelle fission mitochondrial fission regulation of organelle organization organelle organization negative regulation of organelle organization negative regulation of mitochondrial fission regulation of mitochondrial fission regulation of mitochondrion organization system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation placenta development animal organ development positive regulation of gene expression response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to oxygen levels response to abiotic stimulus epithelium development tissue development epithelial cell differentiation cell surface receptor protein serine/threonine kinase signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of BMP signaling pathway BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway response to BMP transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway lipid storage negative regulation of lipid localization maintenance of location regulation of lipid storage negative regulation of lipid storage SMAD protein signal transduction regulation of SMAD protein signal transduction negative regulation of SMAD protein signal transduction protein localization establishment of protein localization cellular localization nitrogen compound transport lipoprotein transport protein transport cellular macromolecule localization lipoprotein localization negative regulation of transforming growth factor beta receptor signaling pathway regulation of transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway negative regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration regulation of locomotion regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration negative regulation of cell motility cell migration cell motility locomotion negative regulation of cell migration cellular response to low-density lipoprotein particle stimulus response to lipoprotein particle cellular response to lipoprotein particle stimulus negative regulation of connective tissue replacement involved in inflammatory response wound healing negative regulation of tissue remodeling wound healing involved in inflammatory response negative regulation of connective tissue replacement regulation of connective tissue replacement involved in inflammatory response wound healing connective tissue replacement response to wounding wound healing connective tissue replacement involved in inflammatory response wound healing regulation of tissue remodeling inflammatory response to wounding tissue remodeling regulation of connective tissue replacement myeloid leukocyte differentiation hemopoiesis mononuclear cell differentiation myeloid cell differentiation monocyte differentiation leukocyte differentiation response to lipid fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation regulation of cellular response to insulin stimulus positive regulation of transcription by RNA polymerase II glucose homeostasis carbohydrate homeostasis white fat cell differentiation macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation connective tissue development adipose tissue development positive regulation of adipose tissue development regulation of adipose tissue development positive regulation of multicellular organismal process cholesterol storage negative regulation of cholesterol storage regulation of cholesterol storage regulation of osteoblast differentiation negative regulation of osteoblast differentiation osteoblast differentiation ossification regulation of adiponectin secretion positive regulation of establishment of protein localization positive regulation of adiponectin secretion adiponectin secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion endocrine hormone secretion positive regulation of protein localization regulation of hormone secretion regulation of protein localization positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion signal release secretion regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport positive regulation of protein secretion endocrine process regulation of cellular localization hormone transport regulation of signaling receptor activity negative regulation of molecular function negative regulation of signaling receptor activity sequestering of triglyceride negative regulation of sequestering of triglyceride regulation of sequestering of triglyceride negative regulation of muscle adaptation striated muscle adaptation negative regulation of muscle hypertrophy regulation of system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy in response to stress muscle adaptation cardiac muscle adaptation cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy regulation of muscle adaptation negative regulation of cardiac muscle hypertrophy in response to stress striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy negative regulation of cardiac muscle adaptation regulation of cardiac muscle adaptation negative regulation of cardiac muscle hypertrophy muscle hypertrophy in response to stress response to nutrient levels response to nutrient	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle membraneless organelle intracellular membraneless organelle chromatin chromosome cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle membraneless organelle intracellular membraneless organelle chromatin chromosome RNA polymerase II transcription regulator complex nucleus nuclear protein-containing complex transcription regulator complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR010011	Nuclear receptor coactivator, DUF1518	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR028819	Nuclear receptor coactivator 1, basic helix-loop-helix	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR017426	Nuclear receptor coactivator	Family
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR014935	Nuclear receptor coactivator, receptor-binding domain	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR014920	Nuclear receptor coactivator, Ncoa-type, interlocking	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR035965	PAS domain superfamily	Homologous Superfamily
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR037077	Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily	Homologous Superfamily
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR013767	PAS fold	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR000014	PAS domain	Domain
E [auth B], F [auth V], G [auth E], H [auth Y]	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A, C [auth U]	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A, C [auth U]	IPR021780	Nuclear/hormone receptor activator site AF-1	Domain
A, C [auth U]	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A, C [auth U]	IPR000003	Retinoid X receptor/HNF4	Family
A, C [auth U]	IPR050274	Nuclear hormone receptor family NR2 subfamily	Family
A, C [auth U]	IPR001723	Nuclear hormone receptor	Family
A, C [auth U]	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A, C [auth U]	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
B [auth D], D [auth X]	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
B [auth D], D [auth X]	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
B [auth D], D [auth X]	IPR001723	Nuclear hormone receptor	Family
B [auth D], D [auth X]	IPR003077	Peroxisome proliferator-activated receptor gamma	Family
B [auth D], D [auth X]	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
B [auth D], D [auth X]	IPR003074	Peroxisome proliferator-activated receptor	Family
B [auth D], D [auth X]	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
B [auth D], D [auth X]	IPR022590	Peroxisome proliferator-activated receptor gamma, N-terminal	Domain
B [auth D], D [auth X]	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth B], F [auth V], G [auth E], H [auth Y]	Pharos: Q15788	breast carcinoma breast cancer Mammary Neoplasms, Experimental prostate cancer endometriosis ovarian cancer psoriasis adenoma diffuse large B-cell lymphoma glioblastoma malignant glioma astrocytic tumor invasive ductal breast carcinoma osteosarcoma atypical teratoid rhabdoid tumor breast carcinoma breast cancer Mammary Neoplasms, Experimental prostate cancer endometriosis ovarian cancer psoriasis adenoma diffuse large B-cell lymphoma glioblastoma malignant glioma astrocytic tumor invasive ductal breast carcinoma osteosarcoma atypical teratoid rhabdoid tumor cancer large cell medulloblastoma myopathy
A, C [auth U]	Pharos: P19793	prostate cancer lesion of sciatic nerve sciatic neuropathy thyroid gland carcinoma amyotrophic lateral sclerosis type 1 thyroid adenoma malignant mesothelioma Sciatic Neuritis thyroid cancer astrocytic tumor invasive ductal breast carcinoma MALT lymphoma osteosarcoma pituitary cancer B-cell chronic lymphocytic leukemia prostate cancer lesion of sciatic nerve sciatic neuropathy thyroid gland carcinoma amyotrophic lateral sclerosis type 1 thyroid adenoma malignant mesothelioma Sciatic Neuritis thyroid cancer astrocytic tumor invasive ductal breast carcinoma MALT lymphoma osteosarcoma pituitary cancer B-cell chronic lymphocytic leukemia lung carcinoma medulloblastoma ovarian cancer primary cutaneous T-cell lymphoma interstitial cystitis large cell medulloblastoma pancreatic ductal adenocarcinoma
B [auth D], D [auth X]	Pharos: P37231	familial partial lipodystrophy type 2 diabetes mellitus obesity disorder psoriasis Barrett esophagus glomerulonephritis atherosclerosis Crohn disease hypertensive disorder diabetes mellitus melanoma colorectal cancer Alzheimer disease Diabetes Mellitus, Experimental metabolic disease familial partial lipodystrophy type 2 diabetes mellitus obesity disorder psoriasis Barrett esophagus glomerulonephritis atherosclerosis Crohn disease hypertensive disorder diabetes mellitus melanoma colorectal cancer Alzheimer disease Diabetes Mellitus, Experimental metabolic disease acute lung injury leukostasis giant cell glioblastoma congestive heart failure ulcerative colitis antiphospholipid syndrome PPARG-related familial partial lipodystrophy autosomal dominant polycystic kidney disease malignant pancreatic neoplasm monogenic obesity thyroid adenoma kidney failure ACTH-dependent Cushing syndrome non-alcoholic fatty liver disease adenocarcinoma tubular adenocarcinoma granular cell carcinoma liver disease malignant colon neoplasm T-cell non-Hodgkin lymphoma thyroid gland carcinoma gliosarcoma liver cancer ileocolitis autoimmune disease malignant ependymoma diabetic kidney disease breast fibroadenoma maturity-onset diabetes of the young ductal breast carcinoma in situ esophageal adenocarcinoma kidney disease acquired metabolic disease large cell medulloblastoma colon carcinoma acute kidney failure thyroid gland papillary carcinoma colorectal carcinoma tuberculosis lipodystrophy cribriform carcinoma of breast pancreatic intraductal papillary-mucinous neoplasm lung adenocarcinoma polycystic kidney disease 2 hepatocellular carcinoma hyperinsulinism lysosomal lipid storage disorder cutaneous melanoma malignant glioma primitive neuroectodermal tumor inherited lipid metabolism disorder benign colon neoplasm interstitial cystitis medulloblastoma subarachnoid hemorrhage ischemia reperfusion injury cerebrovascular disorder thyroid cancer, nonmedullary, 2 colonic neoplasm gastric cancer lipoatrophic diabetes osteoarthritis glioma susceptibility 1 coronary artery disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia heart failure arteriosclerosis disorder lung cancer hereditary diffuse gastric adenocarcinoma atopic eczema prediabetes syndrome inborn carbohydrate metabolic disorder breast carcinoma MALT lymphoma pustulosis palmaris et plantaris invasive ductal breast carcinoma cancer schizophrenia ischemic disease thyroid cancer neurodegenerative disease leprosy non-small cell lung carcinoma gastric neoplasm congenital generalized lipodystrophy osteoarthritis susceptibility 1 cribriform carcinoma pancreatic intraductal papillary-mucinous carcinoma Hashimoto thyroiditis liver neoplasm Crohn's colitis pancreatic neoplasm lung carcinoma Cushing disease due to pituitary adenoma hyperglycemia