3D View: 4J97

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.

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RCSB PDB Mol* Viewer 2.11.1 [12/17/2024, 1:59:56 PM]
Sequence of
     ​M​​G​​S​​S​​H​​H​​H​​H​​H​​H​     ​S​​Q​​D​​P​​M​​L​​A​​G​​V​​S​     ​E​​Y​​E​​L​​P​​E​​D​​P​​K​​W​475  ​E​​F​​P​​R​​D​​K​​L​​T​​L​​G​485  ​K​​P​​L​​G​​E​​G​​A​​F​​G​​Q​495  ​V​​V​​M​​A​​E​​A​​V​​G​​I​​D​     ​K​​D​​K​​P​​K​​E​​A​​V​​T​​V​515  ​A​​V​​K​​M​​L​​K​​D​​D​​A​​T​525  ​E​​K​​D​​L​​S​​D​​L​​V​​S​​E​535  ​M​​E​​M​​M​​K​​M​​I​​G​​K​​H​545  ​K​​N​​I​​I​​N​​L​​L​​G​​A​​C​555  ​T​​Q​​D​​G​​P​​L​​Y​​V​​I​​V​565  ​E​​Y​​A​​S​​K​​G​​N​​L​​R​​E​575  ​Y​​L​​R​​A​​R​​R​​P​​P​​G​​M​     ​E​​Y​​S​​Y​​D​​I​​N​​R​​V​​P​595  ​E​​E​​Q​​M​​T​​F​​K​​D​​L​​V​605  ​S​​C​​T​​Y​​Q​​L​​A​​R​​G​​M​615  ​E​​Y​​L​​A​​S​​Q​​K​​C​​I​​H​625  ​R​​D​​L​​A​​A​​R​​N​​V​​L​​V​635  ​T​​E​​N​​N​​V​​M​​K​​I​​A​​D​645  ​F​​G​​L​​A​​R​​D​​I​​N​​N​​I​655  ​D​​Y​​Y​​K​​E​​T​​T​​N​​G​​R​665  ​L​​P​​V​​K​​W​​M​​A​​P​​E​​A​675  ​L​​F​​D​​R​​V​​Y​​T​​H​​Q​​S​685  ​D​​V​​W​​S​​F​​G​​V​​L​​M​​W​695  ​E​​I​​F​​T​​L​​G​​G​​S​​P​​Y​705  ​P​​G​​I​​P​​V​​E​​E​​L​​F​​K​715  ​L​​L​​K​​E​​G​​H​​R​​M​​D​​K​725  ​P​​A​​N​​C​​T​​N​​E​​L​​Y​​M​735  ​M​​M​​R​​D​​C​​W​​H​​A​​V​​P​745  ​S​​Q​​R​​P​​T​​F​​K​​Q​​L​​V​755  ​E​​D​​L​​D​​R​​I​​L​​T​​L​​T​     ​T​​N​​E​​E​
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