Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor NADH, Mn++, and allosteric activator fumarate

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RCSB PDB Mol* Viewer 2.10.6 [10/28/2024, 3:56:31 PM]
Sequence of
21   ​I​​K​​E​​K​​G​​K​​P​​L​​MSE​​L​31   ​N​​P​​R​​T​​N​​K​​G​​MSE​​A​​F​41   ​T​​L​​Q​​E​​R​​Q​​MSE​​L​​G​​L​51   ​Q​​G​​L​​L​​P​​P​​K​​I​​E​​T​61   ​Q​​D​​I​​Q​​A​​L​​R​​F​​H​​R​71   ​N​​L​​K​​K​​MSE​​T​​S​​P​​L​​E​81   ​K​​Y​​I​​Y​​I​​MSE​​G​​I​​Q​​E​91   ​R​​N​​E​​K​​L​​F​​Y​​R​​I​​L​101  ​Q​​D​​D​​I​​E​​S​​L​​MSE​​P​​I​111  ​V​​Y​​T​​P​​T​​V​​G​​L​​A​​C​121  ​S​​Q​​Y​​G​​H​​I​​F​​R​​R​​P​131  ​K​​G​​L​​F​​I​​S​​I​​S​​D​​R​141  ​G​​H​​V​​R​​S​​I​​V​​D​​N​​W​151  ​P​​E​​N​​H​​V​​K​​A​​V​​V​​V​161  ​T​​D​​G​​E​​R​​I​​L​​G​​L​​G​171  ​D​​L​​G​​V​​Y​​G​​MSE​​G​​I​​P​181  ​V​​G​​K​​L​​C​​L​​Y​​T​​A​​C​191  ​A​​G​​I​​R​​P​​D​​R​​C​​L​​P​201  ​V​​C​​I​​D​​V​​G​​T​​D​​N​​I​211  ​A​​L​​L​​K​​D​​P​​F​​Y​​MSE​​G​221  ​L​​Y​​Q​​K​​R​​D​​R​​T​​Q​​Q​231  ​Y​​D​​D​​L​​I​​D​​E​​F​​MSE​​K​241  ​A​​I​​T​​D​​R​​Y​​G​​R​​N​​T​251  ​L​​I​​Q​​F​​E​​D​​F​​G​​N​​H​261  ​N​​A​​F​​R​​F​​L​​R​​K​​Y​​R​271  ​E​​K​​Y​​C​​T​​F​​N​​D​​D​​I​281  ​Q​​G​​T​​A​​A​​V​​A​​L​​A​​G​291  ​L​​L​​A​​A​​Q​​K​​V​​I​​S​​K​301  ​P​​I​​S​​E​​H​​K​​I​​L​​F​​L​311  ​G​​A​​G​​E​​A​​A​​L​​G​​I​​A​321  ​N​​L​​I​​V​​MSE​​S​​MSE​​V​​E​​N​331  ​G​​L​​S​​E​​Q​​E​​A​​Q​​K​​K​341  ​I​​W​​MSE​​F​​D​​K​​Y​​G​​L​​L​351  ​V​​K​​G​​R​​K​​A​​K​​I​​D​​S​361  ​Y​​Q​​E​​P​​F​​T​​H​​S​​A​​P​371  ​E​​S​​I​​P​​D​​T​​F​​E​​D​​A​381  ​V​​N​​I​​L​​K​​P​​S​​T​​I​​I​391  ​G​​V​​A​​G​​A​​G​​R​​L​​F​​T​401  ​P​​D​​V​​I​​R​​A​​MSE​​A​​S​​I​411  ​N​​E​​R​​P​​V​​I​​F​​A​​L​​S​421  ​N​​P​​T​​A​​Q​​A​​E​​C​​T​​A​431  ​E​​E​​A​​Y​​T​​L​​T​​E​​G​​R​441  ​C​​L​​F​​A​​S​​G​​S​​P​​F​​G​451  ​P​​V​​K​​L​​T​​D​​G​​R​​V​​F​461  ​T​​P​​G​​Q​​G​​N​​N​​V​​Y​​I​471  ​F​​P​​G​​V​​A​​L​​A​​V​​I​​L​481  ​C​​N​​T​​R​​H​​I​​S​​D​​S​​V​491  ​F​​L​​E​​A​​A​​K​​A​​L​​T​​S​501  ​Q​​L​​T​​D​​E​​E​​L​​A​​Q​​G​511  ​R​​L​​Y​​P​​P​​L​​A​​N​​I​​Q​521  ​E​​V​​S​​I​​N​​I​​A​​I​​K​​V​531  ​T​​E​​Y​​L​​Y​​A​​N​​K​​MSE​​A​541  ​F​​R​​Y​​P​​E​​P​​E​​D​​K​​A​551  ​K​​Y​​V​​K​​E​​R​​T​​W​​R​​S​561  ​E​​Y​​D​​S​​L​​L​​P​​D​​V​​Y​571  ​E​​W​​P​​E​​S​​A​​S​​S​​P​​P​     ​V​​I​​T​​E​
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Asm Id
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